DNA Testing and Molecular Screening for Colon Cancer
نویسندگان
چکیده
منابع مشابه
Rapid DNA Extraction Protocol from Stool, Suitable for Molecular Genetic Diagnosis of Colon Cancer
Colorectal cancer (CRC) is one of the most common forms of cancers in the world and is curable if diagnosed at the early stage. Analysis of DNA extracted from stool specimens is a recent advantage to cancer diagnostics. Many protocols have been recommended for DNA extraction from stool, and almost allof them are difficult and time consuming, dealing with high amount of toxic materials like phen...
متن کاملMolecular screening testing for colorectal cancer.
Worldwide, colorectal cancer is diagnosed in f1 million individuals each year, accounting for >9% of all new cancer cases (1). Approximately 529,000 people worldwide die of this disease annually. In 2006, it is estimated that 146,000 cases of colorectal cancer will occur in the United States with 55,000 deaths (2). Colorectal cancer is an excellent candidate for population-based screening becau...
متن کاملScreening for colon cancer
Colorectal cancer screening reduces mortality in individuals 50 years and older. Each of the screening tests currently available has advantages and limitations, and there is no consensus as to which test or combination of tests is best. What is clear, however, is that the rates of colorectal cancer screening remain low. This review summarizes the clinical evidence supporting colorectal cancer s...
متن کاملrapid dna extraction protocol from stool, suitable for molecular genetic diagnosis of colon cancer
colorectal cancer (crc) is one of the most common forms of cancers in the world and is curable if diagnosed at the early stage. analysis of dna extracted from stool specimens is a recent advantage to cancer diagnostics. many protocols have been recommended for dna extraction from stool, and almost allof them are difficult and time consuming, dealing with high amount of toxic materials like phen...
متن کاملMultitarget stool DNA testing for colorectal-cancer screening.
BACKGROUND An accurate, noninvasive test could improve the effectiveness of colorectal-cancer screening. METHODS We compared a noninvasive, multitarget stool DNA test with a fecal immunochemical test (FIT) in persons at average risk for colorectal cancer. The DNA test includes quantitative molecular assays for KRAS mutations, aberrant NDRG4 and BMP3 methylation, and β-actin, plus a hemoglobin...
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ژورنال
عنوان ژورنال: Clinical Gastroenterology and Hepatology
سال: 2014
ISSN: 1542-3565
DOI: 10.1016/j.cgh.2013.12.007